Proven efficacy of Aleve®: strength and duration vs acetaminophen plus codeine

Two 8-hour studies (N=455) compared 1 dose of Aleve® 440 mg with 1 dose of acetaminophen 600 mg plus codeine 60 mg after surgical removal of 3 or 4 molars (≥1 impacted). From the 3-hour mark onward in both studies, patients who took Aleve® reported significantly reduced pain compared with those taking APAP+codeine (P<0.05).1 The 12-hour strength of Aleve® also gave patients more sustained pain relief per dose, as demonstrated by a longer median time to remedication, versus patients on APAP+codeine (P<0.05), which is commonly prescribed every 4 hours as needed.1,2


Proven efficacy of Aleve®: strength and duration vs acetaminophen

A controlled, single-dose, randomized, double-blind, 12 hour clinical trial compared efficacy and duration of action of 440 mg Aleve® (n=92), 1000 mg acetaminophen (n=89), and placebo (n=45) patients with at least moderate pain after extraction of 3 or 4 third molars.3 The study demonstrated that mean pain relief with Aleve® was significantly superior to both placebo and acetaminophen at hours 4 to 12 after initial dosing (P<0.05).3

In the trial, patients taking acetaminophen required remedication as soon as 3 hours later, and there was no significant difference in pain relief between acetaminophen and placebo at 6 hours.3

Higher patient ratings of pain relief seen with Aleve® than with acetaminophen

In a trial in dental pain, 3 times more patients reported the overall effectiveness of Aleve® as very good or excellent versus acetaminophen. A greater percentage of patients rated acetaminophen as good or fair versus Aleve®.1


Proven duration of Aleve® vs ibuprofen

A single-center, randomized, double-blind, placebo-controlled study demonstrated that the duration of pain relief after a single dose of Aleve® 440 mg was significantly longer than ibuprofen 400 mg in postsurgical dental pain. Significantly fewer Aleve®-treated subjects required rescue medication over a 24-hour period.4

Professional guidelines recommend NSAIDs as first-line minor pain treatment

In response to the increase in prescription opioid abuse, dental associations recommend NSAIDs as first line therapy.5-7 The American Dental Association recommends NSAIDs as first-line therapy for acute pain management,5,6 and the American Association of Oral and Maxillofacial Surgeons recommends NSAIDs as a first-line analgesic therapy for pain management.7 Aleve® is indicated for the temporary relief of minor aches and pains.8

References: 1. Data on file, Bayer Consumer Health. 2. TYLENOL® with codeine Medication Guide. Janssen Pharmaceuticals, Inc.; October 2019. 3. Kiersch TA, Halladay SC, Hormel PC. A single-dose, double-blind comparison of naproxen sodium, acetaminophen, and placebo in postoperative dental pain. Clin Ther. 1994;16(3):394-404. 4. Cooper SA, Desjardins P, Brain P, et al. Longer analgesic effect with naproxen sodium than ibuprofen in post-surgical dental pain: a randomized, double-blind, placebo-controlled, single-dose trial. Curr Med Res Opin. 2019;35(12):2149-2158. doi:10.1080/03007995.2019.1655257 5. American Dental Association announces new policy to combat opioid epidemic. News release. American Dental Association. March 26, 2018. Accessed July 28, 2021. 6. American Dental Association. Statement on the use of opioids in the treatment of dental pain. October 2016. Accessed October 14, 2021. 7. American Association of Oral and Maxillofacial Surgeons. Opioid prescribing: acute and postoperative pain management; 2020. White Paper. Accessed July 28, 2021. 8. Aleve® Caplets. Drug facts. Bayer HealthCare; April 2018.