Explore Growing Evidence and Pain Guidelines Supporting Naproxen Sodium

Aleve® is an OTC pain reliever and fever reducer indicated for temporary relief of minor aches and pains, and the temporary reduction of fever. Many kinds of pain, including minor osteoarthritis (OA) pain, dental pain, and dysmenorrhea have been proven responsive to naproxen sodium,1-3 a long-lasting OTC NSAID and the primary ingredient in Aleve®, at nonprescription strengths.

Click below to learn more about the effectiveness of Aleve® in various pain states in clinical studies, including the recent Aleve® vs hydrocodone plus acetaminophen (HYD+APAP) study comparing a single-dose of each after dental surgery. This single-dose dental study provides evidence for considering an OTC NSAID like Aleve® for minor dental pain.4

References: 1. Couto A, Troullos E, Moon J, Paredes-Diaz A, An R. Analgesic efficacy and safety of non-prescription doses of naproxen sodium in the management of moderate osteoarthritis of the knee or hip. Curr Med Res Opin. 2018;34(10):1747-1753. doi:10.1080/03007995.2018.1437029 2. Kiersch TA, Halladay SC, Hormel PC. A single-dose, double-blind comparison of naproxen sodium, acetaminophen, and placebo in postoperative dental pain. Clin Ther. 1994;16(3):394-404. 3. Milsom I, Minic M, Dawood MY, et al. Comparison of the efficacy and safety of nonprescription doses of naproxen and naproxen sodium with ibuprofen, acetaminophen, and placebo in the treatment of primary dysmenorrhea: a pooled analysis of five studies. Clin Ther. 2002;24(9):1382-1400. doi:10.1016/s0149-2918(02)80043-1 4. Cooper SA, Desjardins PJ, Bertoch T, et al. Analgesic efficacy of naproxen sodium versus hydrocodone/acetaminophen in acute postsurgical dental pain: a randomized, double-blind, placebo-controlled trial. Postgrad Med. 2021. doi:10.1080/00325481.2021.2008180 

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