In a single-dose study vs a widely prescribed opioid, HYD+APAP,

Aleve® was as effective* for dental pain, lasted longer, and was better tolerated1,2

*In hours 0 to 4 of a single-dose dental study of Aleve® (440 mg), hydrocodone plus acetaminophen (HYD+APAP) (10 mg + 650 mg), or placebo. Aleve® is indicated for minor aches and pains.1,3

In a recent, single-center, randomized, double-blind, parallel, placebo-controlled single-dose study, Aleve®, a non-opioid OTC NSAID, was compared with HYD+APAP for dental pain relief1
  • Patients experiencing moderate or severe pain (N=221) after surgical removal of impacted third molars were randomized to receive either a single dose of Aleve® (440 mg [n=90]), HYD+APAP (10 mg + 650 mg [n=87]), or placebo (n=44)1
  • The primary objective was to compare Sum of Pain Intensity Difference from 0 to 12 hours (SPID0-12) after a single oral dose1
    • Secondary objectives were to compare the total pain relief (TOTPAR) over 6 and 12 hours, SPID0-6, time to onset of pain relief, time to first use of rescue medication, and duration of pain intensity at least half gone over 6 and 12 hours1
    • SPID0-4 was also assessed
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*In hours 0 to 4 of a single-dose dental study of Aleve® (440 mg), hydrocodone plus acetaminophen HYD+APAP (10 mg + 650 mg), or placebo. Aleve® is indicated for minor aches and pains.1,3

Based on Sum of Pain Intensity Difference from 0 to 4 hours, or SPID0-41.

mean_pain_intensity_difference_chart.
rescue_medication_chart
better_tolerated_chart.

More treatment-related adverse events were reported with HYD+APAP (n=18) than Aleve® (n=1), including nausea, vomiting, and dizziness.1

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The growing body of evidence offers a compelling argument for first-line use of an NSAID like Aleve® for dental pain, and professional organization guidelines suggest ways of putting NSAIDs into practice.1,4-8

When prescribing any product, HCPs should always consider its efficacy and safety. Before any procedure requiring pain management, dentists should talk with patients about the benefits and risks.

*In hours 0 to 4 of a single-dose dental study of Aleve® (440 mg), hydrocodone plus acetaminophen HYD+APAP (10 mg + 650 mg), or placebo.

See the Proven Results of Aleve® vs Other Dental Pain Relief Options4,5

References: 1. Cooper SA, Desjardins PJ, Bertoch T, et al. Analgesic efficacy of naproxen sodium versus hydrocodone/acetaminophen in acute postsurgical dental pain: a randomized, double-blind, placebo-controlled trial. Postgrad Med. 2021. doi:10.1080/00325481.2021.2008180. 2. Denisco RC, Kenna GA, O’Neil MG, et al. Prevention of prescription opioid abuse: the role of the dentist. J Am Dent Assoc. 2011;142(7):800-810. doi:10.14219 jada.archive.2011.0268 3. Aleve® Caplets. Drug facts. Bayer HealthCare; April 2018. 4. Data on file, Bayer Consumer Health. 5. Kiersch TA, Halladay SC, Hormel PC. A single-dose, double-blind comparison of naproxen sodium, acetaminophen, and placebo in postoperative dental pain. Clin Ther. 1994;16(3):394-404. 6. American Dental Association announces new policy to combat opioid epidemic. News release. American Dental Association. March 26, 2018. Accessed July 28, 2021.https://www.prnewswire.com/news-releases/american-dental-association-announces-new-policy-to-combat-opioidepidemic-300618928.html 7. American Dental Association. Statement on the use of opioids in the treatment of dental pain. October 2016. Accessed October 14, 2021. https://www.ada.org/en/advocacy/current-policies 8. American Association of Oral and Maxillofacial Surgeons. Opioid prescribing: acute and postoperative pain management; 2020. White Paper. Accessed July 28, 2021. https://www.aaoms.org/docs/govt_affairs/advocacy_white_papers/opioid_prescribing.pdf