For Your Patients with Minor Osteoarthritis (OA) Pain

Recommend the Power of Aleve® for Pain Relief1

In a pooled analysis of adults with OA, Aleve® significantly reduced OA pain in the hip and knee1











In the same analysis

Aleve® provided significantly greater pain relief for patients ≥65 years of age (P<0.05)* across the following efficacy endpoints:

  • Pain on passive motion
  • Pain during the day and pain at night
  • Pain on weight bearing

Proven efficacy across multiple studies 

Aleve® vs Tylenol®

  • Aleve® was proven more effective and lasts longer on pain than Tylenol®2,3,§

Based on clinical data from the first 6 hours after initial dosing in one study; from the first 12 hours in another study.

Aleve® vs opioid combination

  • In a recent single-dose study, Aleve® was as effective as, lasted longer, and was better tolerated than hydrocodone plus acetaminophen (HYD+APAP)4

In hours 0 to 4 of a single-dose dental study of Aleve® (440 mg), HYD+APAP (10 mg + 650 mg), or placebo

Aleve® vs a different opioid combination

  • In 2 separate studies with Aleve® vs acetaminophen plus codeine, Aleve® was proven to be stronger from the 3-hour mark onward and last longer5

Aleve® vs ibuprofen

  • In 2 identical, nonprescription dose studies in patients with OA of the knee, Aleve® provided more effective relief of pain at night than ibuprofen6,¶







Major guidelines recommend NSAIDs like naproxen, the active ingredient in Aleve®, as a first-line treatment of OA pain

American Academy of Orthopaedic Surgeons
· Strongly recommends for knee OA pain7

American College of Rheumatology
· Strongly recommends for knee, hip, and/or hand OA8
    – Acetaminophen is conditionally recommended for patients with knee, hip, and/or hand OA

Aleve® is an OTC pain reliever indicated for temporary relief of minor aches and pains including arthritis pain, headache, muscular aches, and toothache.9

*Results of a post hoc pooled analysis evaluating the efficacy and safety of Aleve® for short-term use in patients with osteoarthritis of the knee or hip. In 4 multicenter, multidose, randomized, parallel, double-blind, placebo-controlled studies, Aleve® (age-based dosing regimen: <65 years, 660 mg/day; ≥65 years, 440 mg/day) or placebo was administered over 7 days. Data at baseline and after 7 days in 818 patients who received Aleve® or placebo (n=409 in each group) were pooled and analyzed.

Compared with placebo.

§A controlled, single-dose, clinical trial compared efficacy and duration of action of 440 mg Aleve® (n=92), 1000 mg acetaminophen (n=89), and placebo (n=45) in a randomized, double-blind, 12-hour study of patients with at least moderate pain after extraction of 3 or 4 third molars.

Patients with mild to moderate OA of the knee were randomized to daily doses of naproxen sodium 660 mg, naproxen sodium 440 mg, ibuprofen 1200 mg, or placebo.


References: 1. Couto A, Troullos E, Moon J, Paredes-Diaz A, An R. Analgesic efficacy and safety of non-prescription doses of naproxen sodium in the management of moderate osteoarthritis of the knee or hip. Curr Med Res Opin. 2018;34(10):1747-1753. doi:10.1080/03007995.2018.1437029 2. Kiersch TA, Halladay SC, Hormel PC. A single-dose, double-blind comparison of naproxen sodium, acetaminophen, and placebo in postoperative dental pain. Clin Ther. 1994;16(3):394-404. 3. Daniels SE, Paredes-Diaz A, An R, Centofanti R, Tajaddini A. Significant, long-lasting pain relief in primary dysmenorrhea with low-dose naproxen sodium compared with acetaminophen: a double-blind, randomized, single-dose, crossover study. Curr Med Res Opin. 2019;35(12):2139-2147. doi:10.1080/03007995.2019.1654987 4. Cooper SA, Desjardins PJ, Bertoch T, et al. Analgesic efficacy of naproxen sodium versus hydrocodone/acetaminophen in acute postsurgical dental pain: a randomized, double-blind, placebo-controlled trial. Postgrad Med. 2021. doi:10.1080/00325481.2021.2008180 5. Data on file. Bayer HealthCare. 6. Schiff M, Minic M. Comparison of the analgesic efficacy and safety of nonprescription doses of naproxen sodium and ibuprofen in the treatment of osteoarthritis of the knee. J Rheumatol. 2004;31(7):1373-1383. 7. American Academy of Orthopaedic Surgeons. Treatment of osteoarthritis of the knee—2nd edition. Evidence-based clinical practice guideline. Accessed January 24, 2022. 8. Kolasinski SL, Neogi T, Hochberg MC, et al. 2019 American College of Rheumatology/Arthritis Foundation guideline for the management of osteoarthritis of the hand, hip, and knee. Arthritis Rheumatol. 2020;72(2): 220-233. doi:10.1002/art.41142 9. Aleve® Caplets. Drug facts. Bayer HealthCare; April 2018.